Spray 5-quart slow cooker with cooking spray. In slow cooker, beat milks, melted butter, mustard, salt and peppers with whisk. Add macaroni and 3 1/2 cups of the Cheddar cheese, the cubed cheese and the Parmesan cheese. Cover; cook on Low heat setting 2 1/2 hours or until macaroni is cooked, but not mushy.
Stir to combine. Sprinkle remaining 1/2 cup Cheddar cheese on top; cover and let stand about 15 minutes or until melted.
Meanwhile, in 8-inch skillet, heat 2 tablespoons butter over medium heat. Add bread crumbs; stir to coat. Cook and stir about 3 minutes or until lightly browned. Sprinkle over mac and cheese, and serve.